Cypress Bioscience Inc. to present at the following investor conferences:

August 4, 2008
Oppenheimer Small & Mid Cap Clinical & Regulatory Conference

Michael Hufford, PhD , VP of Corporate Development

August 4, 2008 at 11:10 AM ET and 12:50 PM ET

Oppenheimer Executive Conference Center, New York, NY

Webcast for Company Presentation at 11:10 AM ET

Webcast for Panel Discussion at 12:50 PM ET

June 25, 2008
Jefferies 2nd Annual Healthcare Conference

Michael Hufford, PhD , VP of Corporate Development

June 25, 2008 at 11:15 AM ET

New York, NY

Webcast

June 11, 2008
Seventh Annual Needham & Company Biotechnology & Medical Technology Conference

Ciara Kennedy, PhD, Senior Director, Business Devleopment

June 11, 2008 at 10:00 AM ET

New York Palace Hotel, New York, NY

Webcast

May 28, 2008
FBR Capital Markets 12th Annual Spring Investor Conference

Sabrina Johnson, COO, CFO

May 28, 2008 at 12:50 PM ET

Grand Hyatt Hotel, New York, NY

Webcast

May 22, 2008
Citi Investment Research Global Health Care Conference

Michael Hufford, PhD , VP of Corporate Development

May 22, 2008 at 10:00 AM ET

Hilton Hotel, New York, NY

Webcast

May 6, 2008
Deutsche Bank 33rd Annual Health Care Conference

Michael Hufford, PhD , VP of Corporate Development

May 6, 2008 at 4:10 PM ET

InterContinental Boston Hotel, Boston, MA

Webcast

March 18, 2008
Cowen & Company 28th Annual Health Care Conference

Michael Hufford, PhD , VP of Corporate Development

March 18, 2008 at 2:25 PM ET

Boston Marriott Copley Place , Boston, MA

November 28, 2007
CIBC World Markets 3rd Annual Mid & Small Cap 'Best Ideas' Conference

Michael Hufford, PhD , VP of Corporate Development

November 28, 2007 at 8:00 AM ET

Millennium Broadway Hotel, New York, NY

November 27, 2007
Lazard Capital Markets Fourth Annual Healthcare Conference

Sabrina Johnson, CBO, CFO

November 27, 2007 at 8:00 AM ET

New York Palace Hotel, New York, NY

November 12, 2007
Citi Biotech Day

Sabrina Johnson, CBO, CFO

November 12, 2007 at 2:15 PM ET

Citi Center, New York, NY

November 8, 2007
Webcast to Discuss Clinical Data Presentations for Milnacipran

Forest Laboratories and Cypress Bioscience

November 8, 2007 at 10:00 AM ET

November 6, 2007
CIBC World Markets 18th Annual Healthcare Conference

Sabrina Johnson, CBO, CFO

November 6, 2007 at 10:20 AM ET

Waldorf-Astoria Hotel, New York, NY

September 25, 2007
UBS Global Life Sciences Conference

Sabrina Johnson, CBO, CFO

September 25, 2007 at 11:30 AM ET

Grand Hyatt Hotel, New York, NY

June 27, 2007
Jefferies Healthcare Conference

Jay Kranzler, CEO

June 27, 2007 at 11:50 AM ET

Mandarin Oriental Hotel, New York, NY

May 23, 2007
Citigroup Global Healthcare Conference

Jay Kranzler, CEO

May 23, 2007 at 10:30 AM ET

Hilton New York Hotel, New York, NY

April 12, 2007
CIBC World Markets Annual Biotechnology & Specialty Pharmaceuticals Conference

Sabrina Johnson, CBO, CFO

April 12, 2007 at 9:45 AM ET

Millennium Broadway Hotel, New York, NY

March 6, 2007
Oppenheimer "Positioning Investors for the Next Wave in Pain Management" Conference

Sabrina Johnson, CBO, CFO

March 6, 2007 at 1:10 PM ET

Flatotel Hotel, New York, NY

November 29, 2006
CIBC World Markets 2nd Annual Small & Mid Cap "Best Ideas" Conference

Sabrina Johnson, CBO, CFO

November 29, 2006 at 2:15 PM ET

Millennium Broadway Hotel, New York, NY

November 28, 2006
Lazard Capital Markets Life Sciences Conference

Sabrina Johnson, CBO, CFO

November 28, 2006 at 1:30 PM ET

New York Palace Hotel, New York, NY

November 8, 2006
CIBC World Markets Healthcare Conference

Sabrina Johnson, CBO, CFO

November 8, 2006 at 10:20 AM ET

Waldorf=Astoria Hotel, New York, NY

September 27, 2006
UBS Global Life Sciences Conference

Sabrina Johnson, CBO, CFO

September 27, 2006 at 8:00 AM ET

Grand Hyatt Hotel, New York, NY

June 27, 2006
Jefferies Life Sciences Conference

Sabrina Johnson, CBO, CFO

June 27, 2006 at 1:15 PM ET

Mandarin Oriental Hotel, New York, NY

November 30, 2005
Lazard Capital Markets Life Sciences Conference

Sabrina Johnson, CFO

November 30 at 1:00 PM ET

The New York Palace Hotel, New York, NY

November 8, 2005
CIBC World Markets Healthcare Conference

Sabrina Johnson, CFO

November 8 at 11:00 AM ET

Waldorf=Astoria Hotel, New York, NY

October 26, 2005
C.E. Unterberg, Towbin Life Sciences Conference

Sabrina Johnson, CFO

October 26 at 4:20 PM ET

Palace Hotel, New York, NY

September 29, 2005
UBS Global Life Sciences Conference

Jay Kranzler, CEO

September 29 at 8:00 AM ET

Grand Hyatt Hotel, New York, NY

September 20, 2005
Merriman Curhan Ford Investor Summit Conference

Sabrina Johnson, CFO

September 20 at 10:45 AM PT

Mark Hopkins InterContinental Hotel, San Francisco, CA

September 9, 2005
BioCentury Newsmakers in the Biotech Industry Conference
Jay Kranzler, CEO
September 9 at 10:30 AM ET
Sheraton New York Hotel & Towers, NY

July 28, 2005
Banc of America Specialty Pharmaceuticals Conference
Jay Kranzler, CEO
July 28 at 4:30 PM ET
Southampton Inn, NY

June 2 , 2005
Friedman Billings Ramsey Growth Investor Conference
Jay Kranzler, CEO
June 2nd at 8:20 AM ET
Millennium Broadway Hotel, New York, NY

May 24, 2005
UBS Global Pharmaceuticals Conference
Sabrina Johnson, CFO
May 24th at 8:30 AM ET
Grand Hyatt Hotel, New York, NY

May 19, 2005
Banc of America Health Care Conference
Srinivas Rao, CSO
May 19th at 2:00 PM PT
Four Seasons Hotel, Las Vegas, NV

May 3, 2005
Deutsche Bank Healthcare Conference
Sabrina Johnson, CFO
May 3rd at 10:00 AM ET
Hyatt Regency Baltimore Hotel, Baltimore, MD

April 5, 2005
CIBC Biotechnology & Specialty Pharmaceuticals Conference
Jay Kranzler, CEO
April 5th at 1:15 PM ET
Millennium Broadway Hotel, New York, NY

March 1, 2005
Wells Fargo Healthcare Conference
Jay Kranzler, CEO
March 1st at 12:00 PM ET
St. Regis Hotel, New York, NY

February 23, 2005
BIO CEO & Investor Conference
Jay Kranzler, CEO
February 23rd at 4:00 PM ET
Waldorf Astoria Hotel, New York, NY

February 16, 2005
Smith Barney Citigroup Small & Mid-Cap Conference
Sabrina Johnson, CFO
February 16th at 2:25 PM PT
Four Seasons at Mandalay Bay, Las Vegas, NV

December 16, 2004
Wachovia Securities Ten for '05 Biotechnology Conference
Sabrina Johnson, CFO
December 16th at 10:00 AM ET
Ritz Carlton, Central Park New York, NY

December 7-8, 2004
First Albany Capital Conference
Sabrina Johnson, CFO
December 8th at 2:00 PM

November 30-December 1, 2004
Lazard's Life Sciences Conference
Jay Kranzler, CEO
December 1st at 11:00 AM
Mandarin Oriental, New York, NY

November 18-19, 2004
Granite Financial Healthcare Conference
Denise Woolard, VP Legal and Business Affairs
Presentation Date/Time TBA
Del Mar Marriott, San Diego

November 8-10, 2004
CIBC World Markets Conference
Jay Kranzler, CEO
November 9th at 4:00 PM
The Plaza Hotel, New York, NY
New York, NY

October 26-28, 2004
Rodman & Renshaw Techvest Conference
Sabrina Johnson, CFO
October 28th at 9:45 AM
Waldorf-Astoria, New York, NY

September 27-30, 2004
UBS Global Life Sciences Conference
Sabrina Johnson, VP & CFO
September 29th at 4:00 PM
Grand Hyatt, New York, NY

September 9, 2004
BioCentury Newsmakers Conference
Jay Kranzler, CEO
September 9th at 11:00 AM ET
Millennium Hotel, New York, NY

May 12-14 2004
Rodman & Renshaw Techvest Global Healthcare Conference
Sabrina Johnson, VP & CFO
May 13th at 8:40 AM BST
Claridge's Hotel, London

May 6, 2004
Smith Barney Citigroup 2004 Small & Mid-Cap Conference
Sabrina Johnson, VP & CFO
May 6th at 1:45pm PDT
Four Seasons Hotel, Las Vegas, NV

May 4-5, 2004
Deutsche Bank Healthcare Conference
Jay Kranzler, CEO
May 5th at 2pm EDT
Baltimore Renaissance Harborplace Hotel, Baltimore, MD

April 27-28, 2004
CIBC World Markets’ Annual Biotechnology and Specialty Pharmaceuticals Conference
Jay Kranzler, CEO
April 27th at 4:15 EDT
Millennium Broadway Hotel, New York

April 1, 2004
BioCentury Future Leaders in the Biotech Industry
Jay Kranzler, CEO
April 1st
Millennium Broadway Hotel,New York

March 8-11, 2004
SG Cowen 24th Annual Health Care Conference
Jay Kranzler, CEO
March 9th at 8:00AM EST
The Boston Marriott Copley Place, Boston, MA

February 23-25, 2004
BIO CEO & Investor Conference
Jay Kranzler, CEO- Drug Development Panel Speaker
February 25th at 9:30AM
Waldorf Astoria New York

February 16-19, 2004
Roth Capital Partners 16th Annual Growth Stock Conference
Sabrina Johnson, CFO
February 17th at 9:00AM
St. Regis Dana Point, CA